![]() The platform is efficient at rapidly isolating biomarkers and maintaining the biomolecular integrity of the vesicles.īiologically, small extracellular vesicles are membrane-encapsulated biological vessels found in biofluids such as blood, urine, saliva, semen, breast milk and cerebrospinal fluid released by cells into the extracellular space. The scientists characterized the small extracellular vesicles isolated from the biofluids of cancer patients using the instrument and conducted a three-fold characterization with conventional flow cytometry, advanced imaging flow cytometry, and microRNA sequencing to obtain a high yield of pure extracellular vesicles. In a study published in Scientific Reports, Manju Sharma and a team of scientists in biomedical engineering at the University of Cincinnati Ohio U.S., developed a new insulator-based dielectrophoretic device to rapidly isolate small extracellular vesicles from biofluids and cell culture media, based on their dielectric properties. It is important to efficiently isolate small extracellular vesicles while maintaining the yield and purity to explore their potential in diagnostic, prognostic, and therapeutic applications.Ĭonventional methods of isolation have shortcomings, which include low purity and yield, lengthy extraction procedures, specialized equipment, and high-costs.
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